Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 5/20 | 0.72 |
| ▸ | JAK2 | O60674 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | MTOR | P42345 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | JUN | P05412 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1631045 | 0.92 | SMG1 (0.59) | SMG1JAK2CDK1CDK2MTOR | |
| SCHEMBL1632820 | 0.90 | SMG1 (0.58) | SMG1JAK2CDK1CDK2MTOR | |
| SCHEMBL1633026 | 0.89 | SMG1 (0.59) | SMG1JAK2CDK1CDK2MTOR | |
| SCHEMBL1631108 | 0.84 | SMG1 (0.70) | SMG1JAK2CDK1CDK2MTOR | |
| SCHEMBL1860937 | 0.82 | SMG1 (0.59) | SMG1JAK2CDK1CDK2MTOR | |
| SCHEMBL1631926 | 0.81 | MAP4K1 (0.47) | SMG1JAK2CDK1CDK2MTOR | |
| SCHEMBL1633843 | 0.81 | MAPK10 (0.54) | SMG1JAK2CDK1CDK2MTOR | |
| SCHEMBL13498325 | 0.80 | IKBKB (0.54) | JAK2CDK1CDK2CA12CA1 | |
| SCHEMBL1633521 | 0.80 | BRAF (0.54) | CDK1CDK2MAPK10MAPK8 | |
| SCHEMBL13648583 | 0.79 | JAK2 (0.75) | SMG1JAK2CDK1CDK2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |