Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633064 | 0.84 | MTOR (0.62) | SMG1MTORCA12CA1CA9 | |
| SCHEMBL1632340 | 0.83 | MAPK10 (0.63) | MAPK10JAK2LRRK2CSF1RCDK2 | |
| SCHEMBL1633230 | 0.83 | CA2 (0.52) | JAK2CSF1RCA12CA1CA9 | |
| SCHEMBL1632820 | 0.82 | SMG1 (0.58) | MAPK10JAK2SMG1MTORCA12 | |
| SCHEMBL1632195 | 0.81 | CDK2 (0.56) | JAK2SMG1MTORCA12CA1 | |
| SCHEMBL1633017 | 0.81 | SMG1 (0.72) | MAPK10JAK2LRRK2SMG1MTOR | |
| SCHEMBL1633645 | 0.79 | MAP4K1 (0.62) | MAPK10JAK2LRRK2CSF1RCDK2 | |
| SCHEMBL1632895 | 0.79 | CDK2 (0.53) | SMG1MTORCA12CA1CA9 | |
| SCHEMBL1634125 | 0.79 | MAP4K1 (0.53) | MAPK10JAK2LRRK2CSF1RCDK2 | |
| SCHEMBL3502719 | 0.78 | MTOR (0.62) | SMG1MTORCA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |