Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 3/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | STK4 | Q13043 | 3/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
| ▸ | STK16 | O75716 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633835 | 0.91 | IKBKB (0.47) | CDK2CCNE1IKBKBCCNT1CDK1 | |
| SCHEMBL1632154 | 0.89 | CDK2 (0.46) | CDK2CCNE1IKBKBCCNT1CDK1 | |
| SCHEMBL1631354 | 0.89 | TYK2 (0.54) | CDK2CCNE1IKBKBCCNT1CDK1 | |
| SCHEMBL1632397 | 0.88 | TBK1 (0.57) | CDK2IKBKBCCNT1CDK1CCNB1 | |
| SCHEMBL1633063 | 0.85 | IKBKB (0.53) | CDK2CCNE1IKBKBCCNT1CDK1 | |
| SCHEMBL1632055 | 0.85 | CCNE1 (0.46) | CDK2CCNE1IKBKBCCNT1CDK1 | |
| SCHEMBL1633709 | 0.84 | SYK (0.47) | CDK2CCNE1IKBKBCCNT1CDK1 | |
| SCHEMBL1633524 | 0.83 | JAK2 (0.50) | FGFR4IKBKBAXLFGFR1NUAK1 | |
| SCHEMBL1633354 | 0.82 | CDK1 (0.44) | FGFR4CDK2IKBKBCDK1CDK9 | |
| SCHEMBL1633356 | 0.82 | CDK1 (0.44) | FGFR4CDK2IKBKBCDK1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |