Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | RET | P07949 | 4/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.54 |
| ▸ | PAK4 | O96013 | 3/20 | 0.54 |
| ▸ | LTK | P29376 | 3/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.54 |
| ▸ | MST1R | Q04912 | 3/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724504 | 0.89 | SYK (0.57) | SYKMAPK8JAK2ABL1RET | |
| SCHEMBL1634798 | 0.85 | SYK (0.53) | SYKMAPK8JAK2ABL1RET | |
| SCHEMBL1633134 | 0.79 | BTK (0.52) | SYKJAK2PTK2LRRK2MAPK10 | |
| SCHEMBL1632135 | 0.79 | JAK3 (0.49) | SYKMAPK8JAK2ABL1RET | |
| SCHEMBL1633271 | 0.76 | MAP4K1 (0.57) | SYKMAPK8CDK5MAPK10CDK4 | |
| SCHEMBL1634297 | 0.76 | SYK (0.52) | SYKJAK2LRRK2MAPK10CDK4 | |
| SCHEMBL1632096 | 0.76 | JAK2 (0.59) | SYKMAPK8JAK2ABL1RET | |
| SCHEMBL1633122 | 0.75 | SYK (0.45) | SYKMAPK8JAK2ABL1RET | |
| SCHEMBL1633410 | 0.74 | SYK (0.52) | SYKMAPK8JAK2ABL1RET | |
| SCHEMBL735531 | 0.73 | SYK (1.00) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |