Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.57 |
| ▸ | SYK | P43405 | 4/20 | 0.52 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 6/20 | 0.51 |
| ▸ | CCND1 | P24385 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | CCND2 | P30279 | 3/20 | 0.50 |
| ▸ | CCND3 | P30281 | 3/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724504 | 0.88 | SYK (0.57) | MAP4K1MAPK10SYKMAPK8EGFR | |
| SCHEMBL1632135 | 0.87 | JAK3 (0.49) | MAP4K1SYKMAPK8CDK4CDK2 | |
| SCHEMBL1634204 | 0.85 | IKBKB (0.56) | MAP4K1MAPK10SYKMAPK8MAPK9 | |
| SCHEMBL1633371 | 0.85 | LRRK2 (0.54) | MAP4K1MAPK10SYKCDK4CCND1 | |
| SCHEMBL1634285 | 0.83 | MAP4K1 (0.55) | MAP4K1MAPK10SYKJUNMAPK8 | |
| SCHEMBL24426202 | 0.82 | SYK (0.62) | SYKCDK2CCND3CCNA2 | |
| SCHEMBL29575826 | 0.81 | MAPK10 (0.66) | MAP4K1MAPK10SYKJUNMAPK8 | |
| SCHEMBL1632932 | 0.80 | SYK (0.51) | MAP4K1SYKCDK2CDK1CCNB1 | |
| SCHEMBL18376719 | 0.78 | MAP4K1 (0.62) | MAP4K1MAPK10CDK4CDK2CCNE1 | |
| SCHEMBL29575670 | 0.77 | MAP4K1 (0.52) | MAP4K1MAP4K3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | MAP4K1 48/4885MAPK10 402/4885SYK 4204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.