Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.54 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331561 | 0.92 | BRAF (0.56) | BRAFFLT3PIK3CAMTORPRKDC | |
| SCHEMBL16331973 | 0.89 | BRAF (0.51) | BRAFFLT3PIK3CAMTORPRKDC | |
| SCHEMBL16332689 | 0.88 | MEN1 (0.51) | BRAFFLT3PIK3CAMTORPRKDC | |
| SCHEMBL16331745 | 0.86 | BRAF (0.42) | BRAFEGFRKDRMEN1KMT2A | |
| SCHEMBL16332023 | 0.84 | SMN1; SMN2 (0.42) | BRAFEGFRKDRMEN1KMT2A | |
| SCHEMBL16331795 | 0.82 | BRAF (0.43) | BRAFPIK3CAMTORPRKDCEGFR | |
| SCHEMBL16331388 | 0.82 | BRD4 (0.51) | FLT3EGFRKDRFYN | |
| SCHEMBL16332766 | 0.81 | PIK3CA (0.44) | BRAFPIK3CAPRKDCMAPTEGFR | |
| SCHEMBL16331719 | 0.81 | EGFR (0.42) | BRAFEGFRKDR | |
| SCHEMBL16331454 | 0.81 | BRAF (0.49) | BRAFFLT3EGFRKDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |