Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331533 | 0.92 | BRAF (0.54) | BRAFPIK3CAPRKDCFYNEGFR | |
| SCHEMBL16331795 | 0.87 | BRAF (0.43) | BRAFPIK3CAPRKDCEGFRERBB2 | |
| SCHEMBL16331998 | 0.87 | PTK2 (0.55) | BRAFFYNPTK2 | |
| SCHEMBL16332766 | 0.86 | PIK3CA (0.44) | BRAFPIK3CAPRKDCFYNEGFR | |
| SCHEMBL16332602 | 0.86 | GABRG2 (0.52) | BRAFGABRG2GABRB3GABRA5PIK3CA | |
| SCHEMBL16332000 | 0.85 | BRAF (0.53) | BRAFEGFRERBB2PTK2 | |
| SCHEMBL16331745 | 0.84 | BRAF (0.42) | BRAFEGFR | |
| SCHEMBL16331614 | 0.83 | GABRG2 (0.49) | BRAFGABRG2GABRB3GABRA5PIK3CA | |
| SCHEMBL16331973 | 0.82 | BRAF (0.51) | BRAFGABRG2GABRB3GABRA5PIK3CA | |
| SCHEMBL16332689 | 0.81 | MEN1 (0.51) | BRAFGABRG2GABRB3GABRA5PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |