Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632641 | 0.91 | JAK2 (0.60) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL1633776 | 0.89 | JAK2 (0.59) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL1633914 | 0.88 | JAK2 (0.51) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL13498310 | 0.85 | JAK2 (0.51) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL1634187 | 0.82 | JAK2 (0.57) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL12724803 | 0.82 | JAK1 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632367 | 0.82 | JAK2 (0.55) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL1631106 | 0.82 | JAK2 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634280 | 0.82 | MCHR1 (0.48) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL1632408 | 0.81 | JAK2 (0.56) | JAK2JAK1TYK2JAK3TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |