Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.59 |
| ▸ | JAK1 | P23458 | 3/20 | 0.59 |
| ▸ | TYK2 | P29597 | 3/20 | 0.59 |
| ▸ | JAK3 | P52333 | 3/20 | 0.59 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632641 | 0.93 | JAK2 (0.60) | JAK2JAK1TYK2JAK3SCN9A | |
| SCHEMBL1634270 | 0.90 | TYK2 (0.55) | JAK2JAK1TYK2JAK3SCN9A | |
| SCHEMBL1633264 | 0.89 | JAK2 (0.56) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL13498290 | 0.86 | JAK2 (0.54) | JAK2JAK1TYK2JAK3SCN9A | |
| SCHEMBL1634187 | 0.86 | JAK2 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632878 | 0.85 | JAK2 (0.53) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634396 | 0.85 | JAK2 (0.53) | JAK2JAK1TYK2JAK3SCN9A | |
| SCHEMBL1632698 | 0.85 | JAK2 (0.53) | JAK2JAK1TYK2JAK3SCN9A | |
| SCHEMBL1632967 | 0.85 | JAK2 (0.53) | JAK2JAK1TYK2JAK3SCN9A | |
| SCHEMBL1632762 | 0.85 | JAK2 (0.50) | JAK2JAK1TYK2JAK3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |