Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 7/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 14/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.41 |
| ▸ | RICTOR | Q6R327 | 5/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.41 |
| ▸ | MAPKAP1 | Q9BPZ7 | 5/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332686 | 1.00 | PIK3C3 (0.44) | PIK3C3CHRNB2CHRNA4MTORPIK3CA | |
| SCHEMBL23103865 | 0.84 | PIK3C3 (0.46) | PIK3C3CHRNB2CHRNA4MTORPIK3CA | |
| SCHEMBL27965766 | 0.82 | MTOR (0.55) | PIK3C3MTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL20917110 | 0.82 | MTOR (0.55) | PIK3C3MTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL25147362 | 0.82 | PIK3C3 (0.44) | PIK3C3MTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL17055234 | 0.82 | MTOR (0.55) | PIK3C3MTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL23132845 | 0.80 | PIK3C3 (0.42) | PIK3C3MTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL23114348 | 0.80 | PIK3C3 (0.42) | PIK3C3MTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL23114347 | 0.80 | PIK3C3 (0.42) | PIK3C3MTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL22601578 | 0.80 | PIK3C3 (0.42) | PIK3C3MTORPIK3CAPIK3R1RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085578-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-21 | — | — | US | disclosed |
| US-9085578-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-21 | — | — | US | disclosed |
| US-20150045349-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2015-02-12 | — | — | US | disclosed |
| US-20150045349-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2015-02-12 | — | — | US | disclosed |
| EP-2818473-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2014-12-31 | — | — | EP | disclosed |
| EP-2818473-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2014-12-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045349-A1 | HETEROCYCLIC COMPOUND | TYK2, SSB, UACA | PIK3C3 217/4885CHRNB2 3277/4885CHRNA4 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.