Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 1.00 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 1.00 |
| ▸ | CSNK2B | P67870 | 4/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 1.00 |
| ▸ | PLK1 | P53350 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.60 |
| ▸ | STK17B | O94768 | 2/20 | 0.58 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11982072 | 0.87 | CSNK2A2 (0.78) | NOTUMCSNK2A2CSNK2BCSNK2A1PLK1 | |
| SCHEMBL11962151 | 0.85 | PLK1 (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1PLK1 | |
| SCHEMBL29370624 | 0.75 | CSNK2A2 (0.59) | NOTUMCSNK2A2CSNK2BCSNK2A1PLK1 | |
| SCHEMBL439342 | 0.74 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL24096064 | 0.74 | POLB (0.68) | NOTUMCSNK2A2CSNK2BCSNK2A1HTT | |
| SCHEMBL16333208 | 0.72 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1HTT | |
| SCHEMBL438058 | 0.72 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL439241 | 0.72 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL16333151 | 0.72 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL16333140 | 0.71 | NPSR1 (0.67) | NOTUMCSNK2A2CSNK2BCSNK2A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |