Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 8/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | STK17B | O94768 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16333341 | 0.70 | NOTUM (0.75) | MAP3K8NOTUMALDH1A1HPGDRXFP1 | |
| SCHEMBL439326 | 0.70 | NOTUM (0.57) | MAP3K8NOTUMALDH1A1HPGDALOX15 | |
| SCHEMBL440686 | 0.69 | NOTUM (0.56) | MAP3K8NOTUMALDH1A1HPGDRXFP1 | |
| SCHEMBL438085 | 0.69 | NOTUM (0.77) | MAP3K8NOTUMALDH1A1HPGDMAPK1 | |
| SCHEMBL4421700 | 0.69 | MEN1 (0.55) | ALDH1A1ALOX15 | |
| SCHEMBL16333308 | 0.68 | NOTUM (0.76) | NOTUMALDH1A1HPGDMAPK1RXFP1 | |
| SCHEMBL469141 | 0.68 | NOTUM (0.54) | MAP3K8NOTUMALDH1A1HPGDMAPK1 | |
| SCHEMBL441076 | 0.68 | NOTUM (0.54) | MAP3K8NOTUMALDH1A1HPGDALOX15 | |
| SCHEMBL7056588 | 0.68 | HTT (0.75) | NOTUMALDH1A1HPGDHSD17B10RXFP1 | |
| SCHEMBL8237163 | 0.67 | KDM4E (0.61) | NOTUMALDH1A1HPGDALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |