Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.32 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12432326 | 1.00 | ROCK2 (0.33) | ROCK2CYP26A1CYP24A1HSD11B1 | |
| SCHEMBL12432264 | 0.93 | ROCK2 (0.34) | ROCK2HSD11B1 | |
| SCHEMBL16333628 | 0.93 | ROCK2 (0.34) | ROCK2HSD11B1 | |
| SCHEMBL12432306 | 0.93 | ROCK2 (0.34) | ROCK2HSD11B1 | |
| SCHEMBL4024064 | 0.92 | ROCK2 (0.38) | ROCK2HSD11B1 | |
| SCHEMBL2208729 | 0.92 | ROCK2 (0.38) | ROCK2HSD11B1 | |
| SCHEMBL2208721 | 0.92 | ROCK2 (0.38) | ROCK2HSD11B1 | |
| SCHEMBL12432345 | 0.92 | ROCK2 (0.33) | ROCK2HSD11B1 | |
| SCHEMBL2210272 | 0.92 | ROCK2 (0.38) | ROCK2HSD11B1 | |
| SCHEMBL2022283 | 0.92 | ROCK2 (0.38) | ROCK2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029579-B1 | CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2014-12-31 | — | — | EP | disclosed |