Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 1.00 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.74 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.74 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440651 | 0.87 | NOTUM (0.77) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL438065 | 0.87 | NOTUM (0.77) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL438060 | 0.87 | NOTUM (0.77) | NOTUMCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL441046 | 0.86 | NOTUM (0.76) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL439137 | 0.86 | NOTUM (0.76) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL16333212 | 0.85 | NOTUM (0.74) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL439342 | 0.85 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL16339247 | 0.84 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL16339840 | 0.84 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD | |
| SCHEMBL16339818 | 0.84 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |