SCHEMBL440651

SCHEMBL440651

COC(=O)CSc1ncnc2sc(Br)c(C)c12

nearest known ligand 0.77

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 13/20 0.77
CSNK2A2 P19784 1/20 0.56
CSNK2B P67870 1/20 0.56
CSNK2A1 P68400 1/20 0.56
PRNP P04156 1/20 0.53
KDM4E B2RXH2 2/20 0.51
HPGD P15428 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
POLB P06746 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16333328 0.87 NOTUM (1.00) NOTUMCSNK2A2CSNK2BCSNK2A1KDM4E
SCHEMBL439241 0.86 NOTUM (1.00) NOTUMCSNK2A2CSNK2BCSNK2A1
SCHEMBL438065 0.85 NOTUM (0.77) NOTUMCSNK2A2CSNK2BCSNK2A1PRNP
SCHEMBL439137 0.84 NOTUM (0.76) NOTUMCSNK2A2CSNK2BCSNK2A1PRNP
SCHEMBL16333408 0.81 NOTUM (0.71) NOTUMCSNK2A2CSNK2BCSNK2A1PRNP
SCHEMBL438060 0.80 NOTUM (0.77) NOTUMCSNK2A2CSNK2BCSNK2A1
SCHEMBL439273 0.76 NOTUM (0.71) NOTUMCSNK2A2CSNK2BCSNK2A1PRNP
SCHEMBL8234971 0.76 NOTUM (0.63) NOTUMCSNK2A2CSNK2BCSNK2A1PRNP
SCHEMBL439278 0.75 NOTUM (0.77) NOTUMCSNK2A2CSNK2BCSNK2A1PRNP
SCHEMBL16339840 0.74 NOTUM (1.00) NOTUMCSNK2A2CSNK2BCSNK2A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9611339-B2 Supported double center hybrid polyethylene catalyst, process for preparing the same and use thereof EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2017-04-04 US claimed
US-20120065345-A1 SUPPORTED HYBRID CHROMIUM-BASED CATALYSTS, PROCESSES FOR PREPARING THE SAME, AND USES THEREOF CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2012-03-15 US claimed
EP-1697429-B1 BLOW MOLDING RESINS WITH IMPROVED ESCR UNION CARBIDE CHEM PLASTIC (US) 2011-01-26 EP claimed
EP-1611171-B1 CHROMIUM-BASED CATALYSTS IN MINERAL OIL FOR PRODUCTION OF POLYETHYLENE UNION CARBIDE CHEM PLASTIC (US) 2009-07-01 EP claimed
US-7202313-B2 Chromium-based catalysts in mineral oil for production of polyethylene UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2007-04-10 US claimed
EP-1697429-A1 BLOW MOLDING RESINS WITH IMPROVED ESCR UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2006-09-06 EP claimed
US-20060155081-A1 Chromium-based catalysts in mineral oil for production of polyethylene UNIVATION TECHNOLOGIES, LLC 2006-07-13 US claimed
EP-1611171-A1 CHROMIUM-BASED CATALYSTS IN MINERAL OIL FOR PRODUCTION OF POLYETHYLENE UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2006-01-04 EP claimed
US-6982304-B2 Blow molding resins with improved ESCR UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2006-01-03 US claimed
WO-2005066221-A1 BLOW MOLDING RESINS WITH IMPROVED ESCR UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2005-07-21 WO claimed
US-20050137365-A1 BLOW MOLDING RESINS WITH IMPROVED ESCR UNION CARBIDE CORPORATION 2005-06-23 US claimed
WO-2004094489-A1 CHROMIUM-BASED CATALYSTS IN MINERAL OIL FOR PRODUCTION OF POLYETHYLENE UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2004-11-04 WO claimed
US-5034364-A Silylchromium compounds and polymers as polymerization catalysts MOBIL OIL CORPORATION (US) 1991-07-23 US claimed
US-12409597-B2 High density polyethylene for rigid articles NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) 2025-09-09 US disclosed
US-12331149-B2 Chromium oxide catalyst for ethylene polymerization SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2025-06-17 US disclosed
EP-4133004-B1 HIGH DENSITY POLYETHYLENE FOR RIGID ARTICLES NOVA CHEM INT SA (CH) 2024-04-03 EP disclosed
WO-2005066221-A1 BLOW MOLDING RESINS WITH IMPROVED ESCR UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2005-07-21 WO disclosed
US-20050137365-A1 BLOW MOLDING RESINS WITH IMPROVED ESCR UNION CARBIDE CORPORATION 2005-06-23 US disclosed
WO-2004094489-A1 CHROMIUM-BASED CATALYSTS IN MINERAL OIL FOR PRODUCTION OF POLYETHYLENE UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2004-11-04 WO disclosed
US-5034364-A Silylchromium compounds and polymers as polymerization catalysts MOBIL OIL CORPORATION (US) 1991-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120065345-A1 SUPPORTED HYBRID CHROMIUM-BASED CATALYSTS, PROCESSES FOR PREPARING THE SAME, AND USES THEREOF CRKL, CRBN, MUS81 NOTUM 936/4885CSNK2A2 405/4885CSNK2B 387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.