SCHEMBL16333329

SCHEMBL16333329

Fc1ccc(CN2CCc3ccc(Br)cc3C2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.61
ABCB1 P08183 1/20 0.57
ACACB O00763 1/20 0.52
MEN1 O00255 2/20 0.49
TNF P01375 2/20 0.49
NOD2 Q9HC29 2/20 0.49
NOD1 Q9Y239 2/20 0.49
RAB9A P51151 1/20 0.49
KDM1A O60341 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
CARM1 Q86X55 1/20 0.48
TSHR P16473 1/20 0.47
MAPK1 P28482 1/20 0.47
DRD2 P14416 2/20 0.45
HTR1A P08908 1/20 0.45
HTR2A P28223 1/20 0.45
SLC6A4 P31645 1/20 0.45
HTR7 P34969 1/20 0.45
HRH1 P35367 1/20 0.45
DRD3 P35462 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28113830 0.83 KMT2A (0.61) KMT2AABCB1MEN1TNFNOD2
SCHEMBL28418459 0.80 KMT2A (0.61) KMT2AABCB1MEN1TNFNOD2
SCHEMBL17913803 0.79 TMEM97 (0.60) KMT2AACACBMEN1TNFNOD2
SCHEMBL29576453 0.79 TMEM97 (0.60) KMT2AACACBMEN1TNFNOD2
SCHEMBL28114243 0.79 KMT2A (0.60) KMT2AABCB1MEN1TNFNOD2
SCHEMBL26963021 0.78 KMT2A (0.44) KMT2AABCB1ACACBMEN1TNF
Hydrochloric Acid SCHEMBL1035271 0.78 KMT2A (0.58) KMT2AABCB1MEN1TNFNOD2
SCHEMBL26962886 0.77 CXCR3 (0.50) KMT2AABCB1ACACBDRD2KCNH2
SCHEMBL16724558 0.77 TNF (0.68) KMT2AMEN1TNFNOD2NOD1
SCHEMBL13499612 0.77 KMT2A (0.65) KMT2AABCB1ACACBMEN1TNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3013834-A1 SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES Merck Sharp & Dohme Corp. (US) 2016-05-04 EP disclosed
WO-2014209727-A1 SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2014-12-31 WO disclosed
WO-2014205593-A1 SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2014-12-31 WO disclosed