Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.57 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | STK17B | O94768 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TLR5 | O60602 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16333296 | 0.86 | RXFP1 (0.53) | NOTUMCLK1CDC7LIMK1DBF4 | |
| SCHEMBL16333194 | 0.73 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1HTT | |
| SCHEMBL9042411 | 0.72 | CLK1 (0.67) | CLK1CDC7LIMK1DBF4KDM4E | |
| SCHEMBL30093319 | 0.72 | CLK1 (0.67) | CLK1CDC7LIMK1DBF4KDM4E | |
| SCHEMBL441182 | 0.70 | NOTUM (0.78) | NOTUMCSNK2A2CSNK2BCSNK2A1STK17B | |
| SCHEMBL16333597 | 0.70 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1STK17B | |
| SCHEMBL441103 | 0.70 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1STK17B | |
| SCHEMBL439318 | 0.70 | NOTUM (0.78) | NOTUMCSNK2A2CSNK2BCSNK2A1STK17B | |
| SCHEMBL16333464 | 0.70 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1STK17B | |
| SCHEMBL16333256 | 0.70 | NOTUM (0.60) | NOTUMCDC7LIMK1DBF4CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |