Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.49 |
| ▸ | CLK1 | P49759 | 4/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16333530 | 0.86 | NOTUM (0.57) | RXFP1RAB9ANOTUMCLK1CDC7 | |
| SCHEMBL439326 | 0.74 | NOTUM (0.57) | RXFP1ALDH1A1RAB9ANOTUML3MBTL1 | |
| SCHEMBL16333341 | 0.74 | NOTUM (0.75) | RXFP1ALDH1A1RAB9ANOTUML3MBTL1 | |
| SCHEMBL440686 | 0.73 | NOTUM (0.56) | RXFP1ALDH1A1RAB9ANOTUML3MBTL1 | |
| SCHEMBL469123 | 0.73 | NOTUM (0.53) | RXFP1ALDH1A1RAB9ANOTUML3MBTL1 | |
| SCHEMBL441076 | 0.71 | NOTUM (0.54) | RXFP1ALDH1A1RAB9ANOTUML3MBTL1 | |
| SCHEMBL469141 | 0.71 | NOTUM (0.54) | RXFP1ALDH1A1RAB9ANOTUML3MBTL1 | |
| SCHEMBL438085 | 0.70 | NOTUM (0.77) | RXFP1ALDH1A1RAB9ANOTUMHPGD | |
| SCHEMBL3238599 | 0.70 | ALDH1A1 (0.58) | RXFP1ALDH1A1NOTUML3MBTL1NPSR1 | |
| SCHEMBL16333308 | 0.70 | NOTUM (0.76) | RXFP1ALDH1A1RAB9ANOTUMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |