⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013519 | 1.00 | KDM4E (0.37) | — | |
| SCHEMBL198651 | 0.72 | — | — | |
| SCHEMBL149636 | 0.72 | — | — | |
| SCHEMBL8098714 | 0.72 | NPC1 (0.35) | — | |
| SCHEMBL29385941 | 0.69 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL22400959 | 0.69 | CYP2A6 (0.47) | — | |
| SCHEMBL31742499 | 0.67 | — | — | |
| SCHEMBL29368062 | 0.67 | — | — | |
| SCHEMBL21528038 | 0.67 | — | — | |
| SCHEMBL182768 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4408 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025102245-A1 | SYNTHESIS METHOD FOR DUAL ENDOTHELIN RECEPTOR ANTAGONIST APROCITENTAN | 浙江天宇药业股份有限公司 | 2025-05-22 | — | — | WO | claimed |
| CN-119528820-A | Apricoxiyet Synthesis method of tam | 浙江国邦药业有限公司 | 2025-02-28 | — | — | CN | claimed |
| CN-119504609-A | Alpraxitans an intermediate compound of (C) Alpraxitans and preparation method thereof | 成都启晟合研医药科技有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-119118998-A | Preparation method of CETP inhibitor Obicetrapib (AMG-899) | 上海相辉医药科技有限公司 | 2024-12-13 | — | — | CN | claimed |
| CN-114644594-B | Preparation method of 5-bromo-2-chloropyrimidine | 郑州猫眼农业科技有限公司 | 2024-06-11 | — | — | CN | claimed |
| CN-117736152-A | Synthesis method of dual endothelin receptor antagonist apixitan | 浙江天宇药业股份有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-116283792-A | Preparation method of medical intermediate | 苏州求索生物科技有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-115772127-B | Method for synthesizing 2-cyano-5-bromopyrimidine | 山东佰隆医药有限公司 | 2023-05-16 | — | — | CN | claimed |
| US-11649216-B2 | Method for preparing Macitentan and intermediate compound thereof | Seasons Biotechnology (Taizhou) Co., Ltd. (CN) | 2023-05-16 | — | — | US | claimed |
| CN-116120818-A | Preparation method of bulletproof polyurea elastomer coating | 西京学院 | 2023-05-16 | — | — | CN | claimed |
| EP-2742048-B1 | INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | HYDRA BIOSCIENCES INC (US) | 2016-04-27 | — | — | EP | claimed |
| EP-2742048-A1 | INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | Hydra Biosciences, Inc. (US) | 2014-06-18 | — | — | EP | claimed |
| CN-103265543-A | Inhibiting transient receptor potential ion channel TRPA1 | HYDRA BIOSCIENCES INC | 2013-08-28 | — | — | CN | claimed |
| WO-2013023102-A1 | INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | HYDRA BIOSCIENCES, INC. (US) | 2013-02-14 | — | — | WO | claimed |
| US-20100113491-A1 | SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS | CHAMPIONS BIOTECHNOLOGY, INC | 2010-05-06 | — | — | US | claimed |
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TIDWELL RICHARD R | 2006-12-28 | — | — | US | claimed |
| EP-1736466-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina at Chapel Hill (US) | 2006-12-27 | — | — | EP | claimed |
| EP-0601381-B1 | Process for the production of 2,5 dibromopyridine | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |
| US-5371224-A | Process for preparing 2,5-dibromopyrimidine | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-06 | — | — | US | claimed |
| EP-0601381-A2 | Process for the production of 2,5 dibromopyridine | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-15 | — | — | EP | claimed |