Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634688 | 0.91 | RXFP1 (0.45) | NTRK1PTK2SYKPPIACDK2 | |
| SCHEMBL1633413 | 0.85 | CA1 (0.47) | NTRK1PTK2SYKIKBKBCDK2 | |
| SCHEMBL1634183 | 0.84 | EGFR (0.52) | NTRK1PTK2IKBKBCDK2CDK1 | |
| SCHEMBL1632931 | 0.82 | CA2 (0.50) | PTK2IKBKBPPIACDK2CDK1 | |
| SCHEMBL1632971 | 0.81 | NTRK1 (0.42) | NTRK1PTK2IKBKBCDK2CDK1 | |
| SCHEMBL1633411 | 0.80 | MTOR (0.50) | SYKIKBKBCDK2CDK1CCNA2 | |
| SCHEMBL1632411 | 0.79 | CDK2 (0.41) | NTRK1PTK2IKBKBCDK2CDK1 | |
| SCHEMBL1633872 | 0.76 | CDK2 (0.52) | NTRK1PTK2IKBKBCDK2CDK1 | |
| SCHEMBL1632775 | 0.75 | MAPK10 (0.51) | SYKIKBKBCDK2CDK1JAK2 | |
| SCHEMBL1633821 | 0.74 | STK4 (0.52) | IKBKBCDK2CDK1JAK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |