Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26767255 | 0.84 | METAP1 (0.54) | MAOBCYP19A1CA12CA9ALDH1A1 | |
| SCHEMBL14069462 | 0.84 | METAP1 (0.50) | MAOBCYP19A1CYP3A4ALDH1A1KDM4E | |
| SCHEMBL31525565 | 0.79 | CA12 (0.54) | CA12CA9ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14495775 | 0.79 | CA12 (0.54) | CA12CA9ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10963283 | 0.78 | MAOB (0.52) | MAOBCYP19A1CYP3A4ALDH1A1KDM4E | |
| SCHEMBL26768004 | 0.76 | METAP1 (0.49) | MAOBCYP19A1CA12CA9ALDH1A1 | |
| SCHEMBL26767999 | 0.76 | METAP1 (0.49) | MAOBCYP19A1CA12CA9ALDH1A1 | |
| SCHEMBL31689707 | 0.76 | MAPT (0.59) | MAOBCYP19A1CYP3A4ALDH1A1KDM4E | |
| SCHEMBL68899 | 0.76 | MAPT (0.59) | MAOBCYP19A1CYP3A4ALDH1A1KDM4E | |
| SCHEMBL5369640 | 0.76 | MAOA (0.56) | MAOBCA12CA9ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013832-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | Merck Patent GmbH (DE) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014209980-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2014-12-31 | — | — | WO | disclosed |