Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633457 | 0.92 | EGFR (0.40) | SYKEPHB4MAPK10JUNMAPK8 | |
| SCHEMBL1633436 | 0.87 | MAPK10 (0.50) | SYKMAPK10JUNMAPK8EGFR | |
| SCHEMBL1571308 | 0.86 | SYK (0.46) | SYKEPHB4MAPK10JUNMAPK8 | |
| SCHEMBL1634531 | 0.86 | SYK (0.47) | SYKEPHB4MAPK10JUNMAPK8 | |
| SCHEMBL1633334 | 0.86 | SYK (0.46) | SYKEPHB4MAPK10JAK2TBK1 | |
| SCHEMBL1634528 | 0.84 | SYK (0.47) | SYKEPHB4JAK2TBK1JAK3 | |
| SCHEMBL1633941 | 0.83 | LRRK2 (0.43) | SYKMAPK10JUNMAPK8JAK2 | |
| SCHEMBL13498346 | 0.81 | SYK (0.43) | SYKEPHB4MAPK10MAPK8JAK2 | |
| SCHEMBL1633276 | 0.80 | EGFR (0.50) | MAPK10JUNMAPK8EGFRJAK2 | |
| SCHEMBL1633561 | 0.79 | MAP4K1 (0.42) | SYKEPHB4MAPK10JUNMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |