Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 14/20 | 0.39 |
| ▸ | CDK1 | P06493 | 13/20 | 0.39 |
| ▸ | KDR | P35968 | 12/20 | 0.39 |
| ▸ | CDK4 | P11802 | 4/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633174 | 0.90 | JAK2 (0.45) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL1634851 | 0.88 | BRD4 (0.42) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL1632091 | 0.87 | IKBKB (0.47) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL1633016 | 0.85 | JAK2 (0.62) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL1633745 | 0.84 | TBK1 (0.53) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL1633607 | 0.82 | JAK2 (0.51) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL1632381 | 0.81 | BRD4 (0.38) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL1632510 | 0.81 | IGF1R (0.51) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL1633442 | 0.80 | PTK2 (0.53) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL1633108 | 0.80 | PTK2 (0.51) | BRD4JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |