Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 3/20 | 0.50 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.50 |
| ▸ | CCND1 | P24385 | 3/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634274 | 0.91 | CDK4 (0.51) | CDK2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL13498315 | 0.90 | JAK2 (0.51) | CDK2CCNE1JAK2TBK1LRRK2 | |
| SCHEMBL1634818 | 0.90 | SYK (0.47) | CDK2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL1632896 | 0.87 | MAPK9 (0.49) | CDK2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL1634301 | 0.86 | LRRK2 (0.55) | JAK2LRRK2PTK2MAPK10 | |
| SCHEMBL1633182 | 0.82 | JAK2 (0.54) | CDK2CCNE1JAK2TBK1CCNA2 | |
| SCHEMBL1633410 | 0.81 | SYK (0.52) | CDK2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL1633304 | 0.81 | CCNT1 (0.45) | CDK2CDK1CCNB1LRRK2CCNA2 | |
| SCHEMBL1632890 | 0.80 | CDK2 (0.51) | CDK2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL1633643 | 0.80 | CDK4 (0.51) | CDK2CDK1CDK4CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |