Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CCNH | P51946 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498315 | 0.86 | JAK2 (0.51) | CCNT1CCNA2CDK2CDK9BRD4 | |
| SCHEMBL1633103 | 0.83 | JAK2 (0.44) | CCNT1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL1634818 | 0.82 | SYK (0.47) | CDK1CCNB1CDK2CDK7TDP1 | |
| SCHEMBL1632734 | 0.82 | IGF1R (0.46) | CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL1633570 | 0.81 | CDK2 (0.50) | CDK1CCNB1CCNA2CDK2CDK9 | |
| SCHEMBL1633493 | 0.80 | JAK2 (0.58) | CCNT1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL1632896 | 0.80 | MAPK9 (0.49) | CDK1CCNB1CDK2 | |
| SCHEMBL1634301 | 0.79 | LRRK2 (0.55) | LRRK2 | |
| SCHEMBL1633182 | 0.78 | JAK2 (0.54) | CCNT1CCNA2CDK2CDK9BRD4 | |
| SCHEMBL12724051 | 0.75 | JAK2 (0.48) | CCNT1CDK1CCNB1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |