Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FAP | Q12884 | 6/20 | 0.45 |
| ▸ | PREP | P48147 | 6/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 7/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067528 | 1.00 | MEN1 (0.50) | MEN1ALDH1A1TSHRKMT2AFAP | |
| SCHEMBL1633739 | 0.92 | KMT2A (0.52) | MEN1ALDH1A1TSHRKMT2AFAP | |
| SCHEMBL1632873 | 0.86 | EPHX1 (0.48) | MEN1ALDH1A1TSHRKMT2AEPHX1 | |
| SCHEMBL23314866 | 0.84 | MEN1 (0.51) | MEN1ALDH1A1TSHRKMT2AFAP | |
| SCHEMBL1633733 | 0.84 | MEN1 (0.51) | MEN1ALDH1A1TSHRKMT2AFAP | |
| SCHEMBL1633563 | 0.84 | EPHX1 (0.46) | MEN1ALDH1A1TSHRKMT2AEPHX1 | |
| SCHEMBL1925210 | 0.82 | ACE (0.53) | MEN1ALDH1A1TSHRKMT2AFAP | |
| SCHEMBL14979025 | 0.82 | MEN1 (0.49) | MEN1ALDH1A1TSHRKMT2AFAP | |
| SCHEMBL1000948 | 0.82 | ACE (0.53) | MEN1ALDH1A1TSHRKMT2AFAP | |
| SCHEMBL24488626 | 0.82 | MEN1 (0.49) | MEN1ALDH1A1TSHRKMT2AFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939534-B2 | e.g. (2-{[2-(3-fluorophenyl)ethyl]amino}-6-piperidyl(3-pyridyl))-N-(3-pyridylmethyl)carboxamide; smooth muscle myosin or non-muscle myosin modulator; hypotensive agent; asthma, chronic obstructive pulmonary disease, bronchoconstrictive disease, glaucoma, pre-menstrual cramps, erectile dysfunction | CYTOKINETICS, INC. (US) | 2011-05-10 | — | — | US | claimed |
| US-7932270-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2011-04-26 | — | — | US | claimed |