Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.55 |
| ▸ | JAK1 | P23458 | 11/20 | 0.55 |
| ▸ | JAK3 | P52333 | 10/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 4/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.50 |
| ▸ | MERTK | Q12866 | 4/20 | 0.50 |
| ▸ | TYK2 | P29597 | 3/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15059526 | 1.00 | JAK2 (0.55) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL15059525 | 1.00 | JAK2 (0.55) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL15060022 | 0.88 | JAK1 (0.58) | JAK2JAK1JAK3KDRAURKB | |
| Hydrochloric Acid SCHEMBL15059314 | 0.87 | JAK1 (0.57) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL16337387 | 0.82 | JAK1 (0.56) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL16336889 | 0.82 | JAK1 (0.56) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL15059571 | 0.82 | JAK1 (0.56) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL15060058 | 0.81 | JAK1 (0.56) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL15059223 | 0.80 | JAK1 (0.57) | JAK2JAK1JAK3KDRAURKB | |
| SCHEMBL15058418 | 0.80 | JAK1 (0.53) | JAK2JAK1JAK3KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150005281-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005281-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVES AS KINASE INHIBITORS | JAK2, JAK1, JAK3 | JAK2 1/4885JAK1 2/4885JAK3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.