Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.68 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.68 |
| ▸ | AR | P10275 | 6/20 | 0.66 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630814 | 0.90 | PGR (0.73) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1631048 | 0.88 | PGR (0.74) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1631878 | 0.88 | PGR (0.62) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1629438 | 0.87 | PGR (0.80) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1631079 | 0.87 | PGR (0.62) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630108 | 0.87 | PGR (0.60) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630553 | 0.85 | PGR (0.64) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630731 | 0.85 | PGR (0.72) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1629329 | 0.84 | PGR (0.71) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630826 | 0.84 | PGR (0.74) | PGRNR3C1NR3C2ARSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |