Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | CCNH | P51946 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | STK4 | Q13043 | 5/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633147 | 0.78 | CDK1 (0.53) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1635629 | 0.77 | CDK2 (0.55) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1632497 | 0.75 | AURKA (0.55) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1634277 | 0.75 | SYK (0.52) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1633248 | 0.74 | IKBKB (0.53) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1631112 | 0.74 | IKBKB (0.59) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1634272 | 0.73 | CA2 (0.49) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1632468 | 0.73 | MEN1 (0.55) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL1633718 | 0.72 | CDK2 (0.66) | CCNT1CDK1CCNB1CDK9PIK3CD | |
| SCHEMBL1634576 | 0.72 | IKBKB (0.58) | CCNT1CDK1CCNB1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |