Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | MAT2A | P31153 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 6/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30163600 | 1.00 | KDM4E (0.49) | KDM4ETOP1TOP2AMAT2APRMT5 | |
| SCHEMBL17144042 | 0.92 | TOP1 (0.43) | KDM4ETOP1TOP2AMAT2APRMT5 | |
| SCHEMBL17655673 | 0.84 | KDM4E (0.58) | KDM4ETOP1TOP2APIM1PIM2 | |
| SCHEMBL17655671 | 0.82 | KDM4E (0.52) | KDM4ETOP1TOP2APIM1PIM2 | |
| SCHEMBL16339120 | 0.82 | KDM4E (0.52) | KDM4ETOP1TOP2APIM1PIM2 | |
| SCHEMBL30163607 | 0.81 | KDM4E (0.49) | KDM4ETOP1TOP2AMAT2APIM1 | |
| SCHEMBL16339385 | 0.81 | KDM4E (0.49) | KDM4ETOP1TOP2AMAT2APIM1 | |
| SCHEMBL16338785 | 0.81 | KDM4E (0.49) | KDM4ETOP1TOP2AMAT2APIM1 | |
| SCHEMBL21451040 | 0.79 | TOP1 (0.41) | KDM4ETOP1TOP2AKDM1ALMNA | |
| SCHEMBL16339164 | 0.79 | MAT2A (0.47) | KDM4ETOP1TOP2AMAT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002287-B1 | Thiochromeno[2,3-c]quinolin-12-one derivatives and their use as topoisomerase inhibitors | NAT DEFENSE MEDICAL CENTER (TW) | 2018-01-31 | — | — | EP | claimed |
| EP-3002287-A1 | Thiochromeno[2,3-c]quinolin-12-one derivatives and their use as topoisomerase inhibitors | National Defense Medical Center (TW) | 2016-04-06 | — | — | EP | claimed |
| US-8927717-B1 | Thiochromeno[2,3-c]quinolin-12-one derivatives, preparation method and application thereof | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2015-01-06 | — | — | US | claimed |
| CN-106659765-B | Use of dianhydrogalactitol and analogs or derivatives thereof for treating non-small cell lung cancer and ovarian cancer | 德玛医药 | 2021-08-13 | — | — | CN | disclosed |
| EP-3002287-B1 | Thiochromeno[2,3-c]quinolin-12-one derivatives and their use as topoisomerase inhibitors | NAT DEFENSE MEDICAL CENTER (TW) | 2018-01-31 | — | — | EP | disclosed |
| EP-3002287-A1 | Thiochromeno[2,3-c]quinolin-12-one derivatives and their use as topoisomerase inhibitors | National Defense Medical Center (TW) | 2016-04-06 | — | — | EP | disclosed |
| US-8927717-B1 | Thiochromeno[2,3-c]quinolin-12-one derivatives, preparation method and application thereof | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2015-01-06 | — | — | US | disclosed |