Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634643 | 0.92 | SYK (0.53) | SYKSRCZAP70JAK2JAK1 | |
| SCHEMBL1571587 | 0.92 | CYP1A2 (0.44) | SYKSRCZAP70CYP1A1CYP1A2 | |
| SCHEMBL1632924 | 0.88 | PRKCZ (0.39) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1633274 | 0.88 | PRKCQ (0.45) | SYKSRCZAP70JAK2JAK1 | |
| SCHEMBL1633716 | 0.87 | PRKCZ (0.38) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL13335980 | 0.85 | SYK (0.44) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL13336156 | 0.85 | BRAF (0.41) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL13363268 | 0.85 | PRKCZ (0.39) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1571934 | 0.84 | JAK2 (0.42) | SYKCYP1A2JAK2JAK1TYK2 | |
| SCHEMBL13336215 | 0.84 | BRAF (0.41) | SYKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |