SCHEMBL16339288

SCHEMBL16339288

C[C@@H]1CN(CCCCOc2ccn(-c3ccc(Cl)c(Cl)c3)n2)C[C@@H](C)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 20/20 1.00
KCNH2 Q12809 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL467450 1.00 SIGMAR1 (1.00) SIGMAR1KCNH2
Hydrochloric Acid SCHEMBL1901550 0.99 SIGMAR1 (0.98) SIGMAR1KCNH2
SCHEMBL466960 0.82 SIGMAR1 (0.91) SIGMAR1KCNH2
SCHEMBL467188 0.82 SIGMAR1 (1.00) SIGMAR1
SCHEMBL466942 0.81 SIGMAR1 (0.93) SIGMAR1KCNH2
Hydrochloric Acid SCHEMBL1893422 0.81 SIGMAR1 (0.89) SIGMAR1KCNH2
Hydrochloric Acid SCHEMBL1899735 0.81 SIGMAR1 (0.98) SIGMAR1
Hydrochloric Acid SCHEMBL1896150 0.81 SIGMAR1 (0.91) SIGMAR1KCNH2
SCHEMBL1354886 0.80 SIGMAR1 (0.67) SIGMAR1KCNH2
SCHEMBL467377 0.80 SIGMAR1 (1.00) SIGMAR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2818166-A1 Use of sigma receptor ligands for the prevention and treatment of pain associated to interstitial cystitis/bladder pain syndrome (IC/BPS) Laboratorios del Dr. Esteve S.A. (ES) 2014-12-31 EP disclosed