Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HCK | P08631 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12612181 | 0.89 | DHFR (0.56) | DHFRLRRK2PIK3CB | |
| SCHEMBL10181112 | 0.78 | DHFR (0.50) | DHFRSRCKDR | |
| SCHEMBL4474184 | 0.75 | DHFR (0.50) | DHFRKDR | |
| SCHEMBL3838310 | 0.74 | DHFR (0.56) | DHFR | |
| SCHEMBL29430406 | 0.74 | DHFR (0.52) | DHFRKDR | |
| SCHEMBL4463726 | 0.74 | DHFR (0.52) | DHFRKDR | |
| Hydrochloric Acid SCHEMBL4473311 | 0.73 | DHFR (0.55) | DHFRSRC | |
| SCHEMBL3564713 | 0.72 | BTK (0.49) | LRRK2PRKCISRCABL1EGFR | |
| SCHEMBL28342224 | 0.72 | DHFR (1.00) | DHFRKDR | |
| SCHEMBL30556294 | 0.72 | DHFR (1.00) | DHFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927547-B2 | Pyrimidine derivatives | NOVIGA RESEARCH AB (SE) | 2015-01-06 | — | — | US | claimed |
| EP-2688883-B1 | PYRIMIDINE DERIVATIVES | NOVIGA RES AB (SE) | 2016-05-18 | — | — | EP | disclosed |