Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | LPL | P06858 | 3/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | LIPE | Q05469 | 5/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18483425 | 0.87 | BACE1 (0.34) | BACE1CXCR2LPLLIPGLIPE | |
| SCHEMBL29414892 | 0.87 | BACE1 (0.34) | BACE1CXCR2LPLLIPGLIPE | |
| SCHEMBL18667453 | 0.86 | CXCR2 (0.37) | BACE1CXCR2LPLLIPGLIPE | |
| SCHEMBL16009606 | 0.84 | BACE1 (0.34) | BACE1LPLLIPGDGAT1 | |
| SCHEMBL24456182 | 0.82 | FFAR1 (0.32) | BACE1DGAT1FFAR1 | |
| SCHEMBL29652969 | 0.82 | FFAR1 (0.32) | BACE1DGAT1FFAR1 | |
| SCHEMBL19513476 | 0.81 | CXCR2 (0.40) | CXCR2LPLLIPG | |
| SCHEMBL30773539 | 0.81 | BACE1 (0.32) | BACE1 | |
| SCHEMBL17841530 | 0.80 | DGAT1 (0.31) | DGAT1LIPE | |
| SCHEMBL22202992 | 0.79 | IDO1 (0.35) | CXCR2LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013337-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | Abbvie Inc. (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014210255-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | ABBVIE INC. (US) | 2014-12-31 | — | — | WO | disclosed |