Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102493 | 0.82 | KMT2A (0.65) | KMT2AALDH1A1KDM4ENPC1TP53 | |
| SCHEMBL16340319 | 0.78 | TSHR (0.47) | KMT2AALDH1A1L3MBTL1HTTKDM4E | |
| SCHEMBL1549077 | 0.76 | ALDH1A1 (0.57) | KMT2AALDH1A1HTTKDM4EPOLB | |
| SCHEMBL28075821 | 0.74 | CYP2D6 (0.44) | KMT2AALDH1A1L3MBTL1KDM4ETP53 | |
| SCHEMBL17020099 | 0.73 | CXCR5 (0.53) | KMT2AALDH1A1HTTKDM4EPOLB | |
| Hydrochloric Acid SCHEMBL28802432 | 0.73 | ALDH1A1 (0.53) | KMT2AALDH1A1HTTKDM4EPOLB | |
| SCHEMBL5963706 | 0.72 | ALDH1A1 (0.57) | KMT2AALDH1A1HTTKDM4EPOLB | |
| SCHEMBL6859420 | 0.71 | KDM4E (0.52) | KMT2AALDH1A1L3MBTL1KDM4EPOLB | |
| SCHEMBL14899243 | 0.71 | HTT (0.71) | KMT2AALDH1A1HTTHPGDHSD17B10 | |
| SCHEMBL2340668 | 0.71 | KDM4E (0.55) | KMT2AALDH1A1HTTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013797-A1 | FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS | BeiGene, Ltd. (KY) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014206344-A1 | FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS | BEIGENE, LTD. (GB) | 2014-12-31 | — | — | WO | disclosed |