Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PAICS | P22234 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498253 | 0.95 | JAK2 (0.43) | JAK2JAK1TYK2JAK3RORC | |
| SCHEMBL1634969 | 0.83 | JAK2 (0.44) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL12724549 | 0.81 | JAK2 (0.50) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1632909 | 0.81 | TBK1 (0.53) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL1632937 | 0.80 | PTK2 (0.51) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL1633937 | 0.80 | JAK2 (0.53) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1632769 | 0.80 | SYK (0.40) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL12764435 | 0.80 | JAK2 (0.50) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL3465389 | 0.80 | JAK2 (0.46) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL1634717 | 0.80 | JAK2 (0.50) | JAK2JAK1TYK2JAK3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |