⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657975 | 0.75 | TSHR (0.35) | — | |
| SCHEMBL988365 | 0.72 | — | — | |
| SCHEMBL11409206 | 0.69 | — | — | |
| SCHEMBL10717616 | 0.69 | — | — | |
| SCHEMBL4052206 | 0.69 | — | — | |
| SCHEMBL4416226 | 0.69 | — | — | |
| SCHEMBL250153 | 0.69 | — | — | |
| SCHEMBL10779815 | 0.69 | — | — | |
| SCHEMBL10717619 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL5931393 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-85102955-A | Method for producing olefin copolymer rubber | — | 1986-10-15 | — | — | CN | claimed |
| US-4256902-A | FORMING AN ALKALINE SALT BY REACTING A HYDRAZINE WITH A B,B-DICHLORO-ACRYLOYL CHLORIDE, ACIDIFYING | MONTEDISON S.P.A. (IT) | 1981-03-17 | — | — | US | claimed |
| CN-114845997-A | Aromatic compound and application thereof in preparation of antitumor drugs | 上海喆邺生物科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| US-7932386-B2 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| EP-1919885-B1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2010-04-28 | — | — | EP | disclosed |
| US-20090030203-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-29 | — | — | US | disclosed |
| US-7408069-B2 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1919885-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | Brystol-Myers Squibb Company (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007019210-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-15 | — | — | WO | disclosed |
| US-20070037978-A1 | Amidating chloro-, methyl-, methoxy, ethyl- or ethoxy-substituted aniline with 2,3-dichloroacryloyl chloride, alkanoate salt and inorganic base to form an N-phenyl-2-chloro-3,3-dimethoxypropionamide (that is also claimed), which is reacted with thiourea to form a N-phenyl-2-aminothiazol-5-ylcarboxamide | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-15 | — | — | US | disclosed |
| US-20060046999-A1 | Monocyclic aroylpyridinones as antiinflammatory agents | BAYER HEALTHCARE AG (DE) | 2006-03-02 | — | — | US | disclosed |
| CN-1138856-A | Sabstituted oxazolines | BAYER AG (DE) | 1996-12-25 | — | — | CN | disclosed |
| EP-0076410-B1 | REACTIVE ANTHRAQUINONE DYES | BAYER AG (DE) | 1987-04-08 | — | — | EP | disclosed |
| CN-85102955-A | Method for producing olefin copolymer rubber | — | 1986-10-15 | — | — | CN | disclosed |
| US-4492690-A | Phosphoric and thiophosphoric esters of 5(3)-hydroxypyrazoles exerting an insecticidal action | MONTEDISON S.P.A. (IT) | 1985-01-08 | — | — | US | disclosed |
| EP-0028351-B1 | REACTIVE DYESTUFFS AND THEIR USE IN DYEING MATERIALS CONTAINING OH OR NH | BAYER AG (DE) | 1984-02-22 | — | — | EP | disclosed |
| EP-0076410-A2 | Reactive anthraquinone dyes | BAYER AG (DE) | 1983-04-13 | — | — | EP | disclosed |
| US-4320144-A | Fungicidal use of diphenyl esters of alkylenes | GAF CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| EP-0028351-A2 | Reactive dyestuffs and their use in dyeing materials containing OH or NH | BAYER AG (DE) | 1981-05-13 | — | — | EP | disclosed |
| US-4256902-A | FORMING AN ALKALINE SALT BY REACTING A HYDRAZINE WITH A B,B-DICHLORO-ACRYLOYL CHLORIDE, ACIDIFYING | MONTEDISON S.P.A. (IT) | 1981-03-17 | — | — | US | disclosed |