Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.51 |
| ▸ | SYK | P43405 | 3/20 | 0.51 |
| ▸ | DKK1 | O94907 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632940 | 0.88 | PTK2 (0.56) | MAPK8MAPK10CDK1CDK2PTK2 | |
| SCHEMBL1633611 | 0.88 | SYK (0.54) | MAPK8CDK1CDK2PTK2SYK | |
| SCHEMBL1632476 | 0.86 | MAP3K5 (0.57) | SYKDKK1GSK3BMAP4K1MEN1 | |
| SCHEMBL1633028 | 0.84 | PTK2 (0.57) | MAPK8MAPK10CDK1CDK2PTK2 | |
| SCHEMBL1633311 | 0.84 | CA2 (0.56) | MAPK8MAPK10CDK1CDK2SYK | |
| SCHEMBL1632246 | 0.82 | SYK (0.50) | MAPK8CDK1CDK2SYKDKK1 | |
| SCHEMBL1633521 | 0.81 | BRAF (0.54) | MAPK8MAPK10CDK1CDK2SYK | |
| SCHEMBL1634389 | 0.81 | IKBKB (0.49) | MAPK8MAPK10CDK1CDK2SYK | |
| SCHEMBL1633158 | 0.80 | CA1 (0.55) | MAPK8MAPK10CDK1CDK2DKK1 | |
| SCHEMBL13498325 | 0.80 | IKBKB (0.54) | MAPK8MAPK10CDK1CDK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |