Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.42 |
| ▸ | IKBKB | O14920 | 3/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | STK16 | O75716 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632276 | 0.85 | NTRK1 (0.42) | MAPK10IKBKBPTK2NTRK1TBK1 | |
| SCHEMBL1634505 | 0.81 | TBK1 (0.55) | CDK1MAPK10IKBKBPTK2NTRK1 | |
| SCHEMBL1633768 | 0.78 | PTK2 (0.45) | CDK1CDK2CDK9MAPK10IKBKB | |
| SCHEMBL1632155 | 0.77 | IKBKB (0.46) | CDK1CDK2CDK9MAPK10IKBKB | |
| SCHEMBL1633524 | 0.77 | JAK2 (0.50) | IKBKBPTK2NTRK1TBK1JAK2 | |
| SCHEMBL1633715 | 0.75 | NTRK1 (0.42) | CDK1CDK2CDK9MAPK10IKBKB | |
| SCHEMBL1633214 | 0.74 | MAPK10 (0.50) | CDK1CDK2CDK9MAPK10IKBKB | |
| SCHEMBL1633433 | 0.74 | MAPK10 (0.64) | MAPK10NTRK1JAK2JUNMAPK8 | |
| SCHEMBL1633057 | 0.74 | EGFR (0.51) | CDK1CDK2CDK9MAPK10IKBKB | |
| SCHEMBL13498247 | 0.74 | IKBKB (0.44) | CDK1CDK2CDK9IKBKBPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |