Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | JUN | P05412 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.48 |
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633572 | 0.91 | MAP4K1 (0.53) | MAPK10JUNMAPK8TBK1JAK2 | |
| SCHEMBL1633838 | 0.89 | MAPK10 (0.51) | MAPK10JUNMAPK8TBK1JAK2 | |
| SCHEMBL1633301 | 0.88 | MAPK10 (0.53) | MAPK10JUNMAPK8SYKTBK1 | |
| SCHEMBL1634531 | 0.87 | SYK (0.47) | MAPK10JUNMAPK8SYKTBK1 | |
| SCHEMBL1870096 | 0.86 | MAPK10 (0.58) | MAPK10JUNMAPK8JAK2LRRK2 | |
| SCHEMBL1634794 | 0.85 | CDK4 (0.51) | MAPK10SYKTBK1JAK2LRRK2 | |
| SCHEMBL1633015 | 0.85 | CDK4 (0.51) | MAPK10SYKTBK1JAK2LRRK2 | |
| SCHEMBL1633436 | 0.84 | MAPK10 (0.50) | MAPK10JUNMAPK8SYKTBK1 | |
| SCHEMBL1632917 | 0.84 | SYK (0.50) | MAPK10JUNMAPK8SYKTBK1 | |
| SCHEMBL1633826 | 0.83 | TBK1 (0.62) | SYKTBK1JAK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |