Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GALR3 | O60755 | 1/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16375358 | 0.83 | EGFR (1.00) | EGFR | |
| SCHEMBL16345771 | 0.81 | EGFR (0.70) | EGFR | |
| SCHEMBL16346230 | 0.81 | EGFR (1.00) | EGFR | |
| SCHEMBL16376056 | 0.76 | EGFR (1.00) | EGFRMAPK1 | |
| SCHEMBL5435953 | 0.76 | EGFR (0.53) | EGFRMAPK1NPC1RAB9A | |
| SCHEMBL16346492 | 0.75 | EGFR (0.70) | EGFR | |
| SCHEMBL16376005 | 0.73 | EGFR (0.86) | EGFR | |
| SCHEMBL16345769 | 0.73 | EGFR (0.77) | EGFR | |
| SCHEMBL5431882 | 0.72 | ICAM1 (0.59) | EGFRMAPK1NPC1GALR3NR2F2 | |
| SCHEMBL5433413 | 0.70 | ICAM1 (0.77) | EGFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015000959-A1 | 4-AMINO-6-ARYL[2,3-D]PYRIMIDINES FOR THE INHIBITION OF EGFR TYROSINE KINASE | NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU) (NO) | 2015-01-08 | — | — | WO | disclosed |