Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 1.00 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.52 |
| ▸ | SELE | P16581 | 1/20 | 0.52 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16376056 | 0.85 | EGFR (1.00) | EGFR | |
| SCHEMBL16376062 | 0.85 | EGFR (1.00) | EGFRICAM1SELEVCAM1 | |
| SCHEMBL16346231 | 0.83 | EGFR (0.71) | EGFR | |
| SCHEMBL16345771 | 0.82 | EGFR (0.70) | EGFR | |
| SCHEMBL16376005 | 0.82 | EGFR (0.86) | EGFR | |
| SCHEMBL16345769 | 0.81 | EGFR (0.77) | EGFR | |
| SCHEMBL16376022 | 0.80 | EGFR (0.67) | EGFR | |
| SCHEMBL16345767 | 0.78 | EGFR (0.67) | EGFR | |
| SCHEMBL16346230 | 0.75 | EGFR (1.00) | EGFR | |
| SCHEMBL16375362 | 0.74 | EGFR (0.82) | EGFRICAM1SELEVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015000959-A1 | 4-AMINO-6-ARYL[2,3-D]PYRIMIDINES FOR THE INHIBITION OF EGFR TYROSINE KINASE | NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU) (NO) | 2015-01-08 | — | — | WO | disclosed |