SCHEMBL16346409

SCHEMBL16346409

COC(=O)[C@H](CC(C)(C)F)NC(=O)OC(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
HTT P42858 1/20 0.43
KLK5 Q9Y337 1/20 0.43
CTSS P25774 9/20 0.43
CTSK P43235 8/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CTSL P07711 3/20 0.41
CTSB P07858 2/20 0.41
NFKB1 P19838 2/20 0.41
NFKB2 Q00653 2/20 0.41
RELA Q04206 2/20 0.41
CA12 O43570 1/20 0.40
CA14 Q9ULX7 1/20 0.40
PSENEN Q9NZ42 1/20 0.39
PPARA Q07869 2/20 0.39
PPARG P37231 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15454775 0.90 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL30916044 0.90 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL15454774 0.90 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL18234094 0.90 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL16376523 0.87 CYP1A2 (0.58) CYP1A2CYP2C9CYP2C19HTTCTSS
SCHEMBL3049273 0.86 CTSK (0.47) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL2367410 0.86 CTSK (0.47) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL18109479 0.86 CYP1A2 (0.44) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL18109477 0.86 CYP1A2 (0.44) CYP1A2CYP2C9CYP2C19HTTKLK5
SCHEMBL1146321 0.85 PPARA (0.49) CTSSCTSKCA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015000076-A9 PHOTOCHEMICAL PROCESS FOR THE FLUORINATION OF AN ORGANIC COMPOUND HAVING AN UNACTIVATED SP3 C-H BOND ALECTOS THERAPEUTICS INC. (CA) 2015-08-06 WO disclosed
WO-2015000076-A9 PHOTOCHEMICAL PROCESS FOR THE FLUORINATION OF AN ORGANIC COMPOUND HAVING AN UNACTIVATED SP3 C-H BOND ALECTOS THERAPEUTICS INC. (CA) 2015-08-06 WO disclosed
WO-2015000076-A1 PHOTOCHEMICAL PROCESS FOR THE FLUORTNATION OF AN ORGANIC COMPOUND HAVING AN UNACTIVATED SP3 C-H BOND ALECTOS THERAPEUTICS INC. (CA) 2015-01-08 WO disclosed
WO-2015000076-A1 PHOTOCHEMICAL PROCESS FOR THE FLUORTNATION OF AN ORGANIC COMPOUND HAVING AN UNACTIVATED SP3 C-H BOND ALECTOS THERAPEUTICS INC. (CA) 2015-01-08 WO disclosed