SCHEMBL163468

SCHEMBL163468

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nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.35
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28371829 0.97 HTT (0.33) HTT
SCHEMBL11416515 0.89 TSHR (0.50) HTTTSHR
SCHEMBL6063631 0.77
SCHEMBL28854406 0.75 PDE4A (0.52)
SCHEMBL2968145 0.75 PDE4A (0.52)
SCHEMBL29043020 0.73 PDE4A (0.50)
SCHEMBL907805 0.73 HTT (0.33) HTTTSHR
SCHEMBL524350 0.73
SCHEMBL3255288 0.73 TSHR (0.31) TSHR
SCHEMBL1002608 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112645829-B Chiral synthesis method of ephedrine key intermediate (S) -2-methylamino-1-phenyl-1-acetone 浙江普洛康裕制药有限公司 2022-10-21 CN claimed
CN-104755481-A Solid salt forms of alpha-6-mPEG 6-O-hydroxycolone as opioid agonists and uses thereof NEKTAR THERAPEUTICS 2015-07-01 CN claimed
CN-102753540-B α4β2Ligands for neuronal nicotinic acetylcholine receptors SUVEN LIFE SCIENCES LTD 2014-01-22 CN claimed
EP-2611444-A1 HETEROCYCLYL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS Suven Life Sciences Limited (IN) 2013-07-10 EP claimed
CN-103079566-A Heterocyclyl compounds as histamine H3 receptor ligands SUVEN LIFE SCIENCES LTD 2013-05-01 CN claimed
CN-102020785-B Compatilizer, application thereof in polyphenyleneoxide/nylon alloy and preparation method of polyphenyleneoxide/nylon alloy UNIV HEBEI SCIENCE & TECH 2013-02-13 CN claimed
CN-102753540-A α4β2Ligands for neuronal nicotinic acetylcholine receptors SUVEN LIFE SCIENCES LTD 2012-10-24 CN claimed
WO-2012029070-A1 HETEROCYCLYL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2012-03-08 WO claimed
CN-113710225-B Delivery and retention of active agents within the skin 范德生物公司 2024-06-21 CN disclosed
US-9975999-B2 Liquid organopolysiloxane and uses thereof DOW CORNING TORAY CO., LTD. (JP) 2018-05-22 US disclosed
CN-105237463-B Preparation methods of one kind (3R, 4R) (base of 1 benzyl, 4 methyl piperidine 3) methylamine L bis- to toluoyltartrates 刘卫国 2017-10-10 CN disclosed
CN-104755481-A Solid salt forms of alpha-6-mPEG 6-O-hydroxycolone as opioid agonists and uses thereof NEKTAR THERAPEUTICS 2015-07-01 CN disclosed
US-8912179-B2 Heterocyclyl compounds as histamine H3 receptor ligands SUVEN LIFE SCIENCES LIMITED (IN) 2014-12-16 US disclosed
US-20140364394-A1 Novel Liquid Organopolysiloxane And Uses Thereof DOW TORAY CO., LTD. (JP) 2014-12-11 US disclosed
CN-101257898-A Combinations of eszopiclone and O-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders SEPRACOR INC (US) 2008-09-03 CN disclosed
CN-101103029-A 1,5,6-substituted-2-oxo-3-cyano-1,6a-diaza-tetrahydro-fluoranthenes as anti-infective agents TIBOTEC PHARM LTD (IE) 2008-01-09 CN disclosed
CN-1208688-C Polymers and positive photoresist compositions suitable for use as photoresists AZ ELECTRONIC MATERIALS JAPAN (JP) 2005-06-29 CN disclosed
CN-1530107-A Insulin resistance treatment by growth hormone secretory hormone �Ʒ� 2004-09-22 CN disclosed
CN-1152049-C Treatment of insulin resistance with growth hormone secretagogues �Ʒ� 2004-06-02 CN disclosed
CN-1305608-A 193 NM wavelength positive-working photoresist composition CLARIANT INT LTD (CH) 2001-07-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140364394-A1 Novel Liquid Organopolysiloxane And Uses Thereof ALG1, SGMS1, LOXL1 HTT 2372/4885TSHR 4512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.