LOXL1

Lysyl oxidase homolog 1 · Q08397 · LOXL1 on Sugi Atlas →

1,323 patent compounds predicted against LOXL1, 911 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL19211738)	1.00	2/20
Hydrochloric Acid (SCHEMBL19211740)	1.00	2/20
SCHEMBL19254640	1.00	2/20
SCHEMBL20699505	1.00	2/20
Hydrochloric Acid (SCHEMBL19211695)	0.89	2/20
Hydrochloric Acid (SCHEMBL19211768)	0.89	2/20
SCHEMBL19255140	0.89	2/20
SCHEMBL20699615	0.89	2/20
Hydrochloric Acid (SCHEMBL19211739)	0.87	2/20
Hydrochloric Acid (SCHEMBL20699556)	0.87	2/20
SCHEMBL19255249	0.87	2/20
SCHEMBL20699484	0.87	2/20
Hydrochloric Acid (SCHEMBL19211718)	0.86	2/20
Hydrochloric Acid (SCHEMBL19211721)	0.86	2/20
SCHEMBL19254621	0.85	2/20
SCHEMBL20699495	0.85	2/20
SCHEMBL19255387	0.83	2/20
SCHEMBL20699590	0.83	2/20
SCHEMBL19254637	0.83	2/20
SCHEMBL19255404	0.83	2/20

Clinical trials — most relevant to LOXL1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Trial of PXS-5505 Combined With First Line Atezolizumab Plus Bevacizumab For Treating Patients With Unresectable Hepatocellular Carcinoma	PHASE1/PHASE2	WITHDRAWN
Endometriosis and Microvascular Dysfunction: Role of Inflammation	EARLY_PHASE1	RECRUITING
A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma	nan	COMPLETED
Pelvic Organs Prolapse Treatment Using Neodymium Laser	nan	ACTIVE_NOT_RECRUITING
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme	nan	NOT_YET_RECRUITING
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States	nan	COMPLETED
Gene Expression in Chronic Venous Leg Ulcers	nan	UNKNOWN
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Chronic Kidney Disease : Role of Biological Factors and Apolipoprotein L1 Encoding Gene (APOL1)	nan	COMPLETED
Developing a Management Approach for Patients With Late-Onset Pompe Disease	nan	ACTIVE_NOT_RECRUITING
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis	nan	UNKNOWN
Genetic Testing to Understand and Address Renal Disease Disparities	nan	COMPLETED
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)	nan	COMPLETED
Biomarkers of Lichen Sclerosus	nan	UNKNOWN
Biomarker for Wolman Disease (BioWolman)	nan	WITHDRAWN
Inflammatory Genomics in Human Carotid Artery Disease	nan	COMPLETED
Stone Disease in Children and Their Families	nan	COMPLETED
for Adipose Tissue DIabetes VAriants (fATDIVA)	nan	COMPLETED
Genetic Study of Age-Related Macular Degeneration	nan	COMPLETED
Gene First Approach to Connective Tissue Disease	nan	COMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy	nan	COMPLETED
Stone Centre Urine and Serum Bank	nan	UNKNOWN
Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis	nan	COMPLETED
Correlation Between Myocardial Deformation and Coronary Artery Tortuosity in Patients With Hypertrophic Cardiomyopathy	nan	COMPLETED
Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis (IPF)	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a LOXL1 binder may also engage these)

Protein	Name	Similarity
Q95L39	—	1.000	Q95L39 →
P97873	—	1.000	P97873 →
P28301	—	0.998	P28301 →
Q05063	—	0.998	Q05063 →
LOX	Protein-lysine 6-oxidase	0.997	landscape →
P33072	—	0.996	P33072 →
P16636	—	0.992	P16636 →
Q701R2	—	0.982	Q701R2 →
Q86X29	—	0.981	Q86X29 →
C0HKU1	—	0.980	C0HKU1 →
A6QLD2	—	0.980	A6QLD2 →
Q9VZX1	—	0.979	Q9VZX1 →
Q8R2G6	—	0.979	Q8R2G6 →
Q2THW0	—	0.979	Q2THW0 →
B7TB45	—	0.978	B7TB45 →
O14511	—	0.978	O14511 →
Q2THW8	—	0.978	Q2THW8 →
Q6NSM8	—	0.978	Q6NSM8 →
PAX2	Paired box protein Pax-2	0.977	landscape →
B5TVM2	—	0.977	B5TVM2 →
Q3U2S4	—	0.977	Q3U2S4 →
P30816	—	0.977	P30816 →
Q71H61	—	0.977	Q71H61 →
Q6BCB4	—	0.977	Q6BCB4 →
Q8JZP9	—	0.977	Q8JZP9 →
O95936	—	0.977	O95936 →
E7FBS9	—	0.976	E7FBS9 →
Q6I6G8	—	0.976	Q6I6G8 →
A2T6H5	—	0.976	A2T6H5 →
A1YG01	—	0.976	A1YG01 →