Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 17/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.59 |
| ▸ | PRKDC | P78527 | 15/20 | 0.59 |
| ▸ | ABL1 | P00519 | 14/20 | 0.59 |
| ▸ | EGFR | P00533 | 14/20 | 0.59 |
| ▸ | HCK | P08631 | 14/20 | 0.59 |
| ▸ | SRC | P12931 | 14/20 | 0.59 |
| ▸ | KDR | P35968 | 14/20 | 0.59 |
| ▸ | MTOR | P42345 | 14/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 13/20 | 0.59 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16347751 | 0.88 | PIK3CD (0.70) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL16347507 | 0.85 | PIK3CG (0.73) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL9884116 | 0.80 | PIK3CD (0.64) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL9884086 | 0.79 | PIK3CD (0.74) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL7908396 | 0.79 | PIK3CD (0.81) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL9884190 | 0.78 | PIK3CG (0.58) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL9884087 | 0.78 | PIK3CG (0.81) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL130500 | 0.78 | PIK3CA (0.76) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL9884135 | 0.76 | PIK3CG (0.62) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL9884134 | 0.76 | PIK3CG (0.58) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016955-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | Rhizen Pharmaceuticals S.A. (CH) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015001491-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2015-01-08 | — | — | WO | disclosed |