Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.70 |
| ▸ | ABL1 | P00519 | 15/20 | 0.70 |
| ▸ | EGFR | P00533 | 15/20 | 0.70 |
| ▸ | HCK | P08631 | 15/20 | 0.70 |
| ▸ | SRC | P12931 | 15/20 | 0.70 |
| ▸ | KDR | P35968 | 15/20 | 0.70 |
| ▸ | MTOR | P42345 | 15/20 | 0.70 |
| ▸ | PRKDC | P78527 | 15/20 | 0.70 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.70 |
| ▸ | PI4KB | Q9UBF8 | 11/20 | 0.70 |
| ▸ | BTK | Q06187 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16347559 | 0.88 | PIK3CG (0.59) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL16347507 | 0.85 | PIK3CG (0.73) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL18874474 | 0.83 | PIK3CD (0.72) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884123 | 0.80 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL14086589 | 0.80 | PIK3CD (0.76) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884082 | 0.79 | PIK3CD (0.78) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884073 | 0.79 | PIK3CG (0.82) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884124 | 0.79 | PIK3CG (0.74) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL7908403 | 0.79 | PIK3CD (0.89) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884130 | 0.78 | PIK3CG (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016955-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | Rhizen Pharmaceuticals S.A. (CH) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015001491-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2015-01-08 | — | — | WO | disclosed |