Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 7/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | WNT1 | P04628 | 5/20 | 0.39 |
| ▸ | JUN | P05412 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633642 | 0.92 | MAP3K5 (0.48) | MAP3K5MAP4K1SYKSCN9AGSK3B | |
| SCHEMBL13498347 | 0.86 | MAP4K1 (0.45) | MAP3K5MAP4K1SYKGSK3BDYRK1A | |
| SCHEMBL1633202 | 0.80 | MAP4K1 (0.54) | MAP3K5MAP4K1SCN9AGSK3BDYRK1A | |
| SCHEMBL1632123 | 0.79 | MAP3K5 (0.44) | MAP3K5MAP4K1SYKIKBKB | |
| SCHEMBL13498314 | 0.79 | MAP4K1 (0.45) | MAP3K5MAP4K1SYKJUNMAPK10 | |
| SCHEMBL1632083 | 0.77 | IKBKB (0.47) | SYKIKBKB | |
| SCHEMBL12725033 | 0.76 | MAP3K5 (0.44) | MAP3K5MAP4K1SYKIKBKB | |
| SCHEMBL1633269 | 0.76 | IKBKB (0.48) | SYKDYRK1AIKBKB | |
| SCHEMBL13252801 | 0.76 | MAP3K5 (0.69) | MAP3K5MAP4K1SYKJUNMAPK10 | |
| SCHEMBL1870367 | 0.76 | MAP3K5 (0.69) | MAP3K5MAP4K1JUNMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |