Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 18/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632325 | 0.92 | HRH3 (0.40) | MAP4K1 | |
| SCHEMBL1633106 | 0.82 | IKBKB (0.49) | MAP4K1MAP4K3CAMK2D | |
| SCHEMBL1634287 | 0.81 | IGF1R (0.47) | MAP4K1MAP4K3CAMK2D | |
| SCHEMBL1633416 | 0.78 | MAP4K1 (0.54) | MAP4K1MAP4K3 | |
| SCHEMBL1634285 | 0.77 | MAP4K1 (0.55) | MAP4K1MAP4K3 | |
| SCHEMBL1633516 | 0.76 | IGF1R (0.49) | — | |
| SCHEMBL1632828 | 0.75 | IKBKB (0.48) | — | |
| SCHEMBL1633319 | 0.75 | JAK3 (0.49) | CAMK2D | |
| SCHEMBL1633852 | 0.74 | JAK2 (0.56) | — | |
| SCHEMBL1633471 | 0.74 | CDK2 (0.47) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |