Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.54 |
| ▸ | JUN | P05412 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632143 | 0.79 | MAP4K1 (0.58) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL1634873 | 0.78 | MAP4K1 (0.44) | MAP4K1MAP4K3 | |
| SCHEMBL1632404 | 0.77 | MAPK10 (0.63) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL1632325 | 0.76 | HRH3 (0.40) | MAP4K1 | |
| SCHEMBL1633852 | 0.71 | JAK2 (0.56) | — | |
| SCHEMBL1632340 | 0.70 | MAPK10 (0.63) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL30512125 | 0.69 | MAP4K1 (0.59) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL30512124 | 0.69 | MAP4K1 (0.61) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL25880624 | 0.69 | MAP4K1 (0.61) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL25882556 | 0.68 | MAP4K1 (0.57) | MAP4K1JUNMAPK10MAPK8MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |